LOX Antibody - BSA Free NB100-2530 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemLOX Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $329.00Supplier Page View Company Product Page
Catalog NumberNB100-2530
ImmunogenA cocktail of two synthetic peptides; one made to a region of the human LOX protein within residues 300-350 (NB100-2528) and one within residues 200-300 (NB100-2527). [Swiss-Prot P28300]
Quantity0.05 ml (also 0.025 ml)
HostRabbit
FormatPBS
TargetLOX
ApplicationsIF/IHC,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Immunocytochemistry/ Immunofluorescence
Conjugate/TagUnconjugated
ReactivityBovine,Human,Mouse,Porcine,Rat
NCBI Full Gene Namelysyl oxidase
Concentration1.0 mg/ml
ClonalityPolyclonal
PurityImmunogen affinity purified
Research AreaCancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Signal Transduction
NCBI Gene AliasesAAT10
IsotypeIgG
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this LOX antibody be used to study its role in endometriosis?

Yes, the LOX antibody has been utilized in research examining the dysregulation of lysyl oxidase expression in endometriotic lesions. In a study, the antibody was employed for immunohistochemistry to assess LOX protein levels in endometrial biopsies, revealing its differential expression in patients with endometriosis compared to controls, which may implicate LOX in the invasiveness and progression of endometriotic lesions ().

Is this antibody effective for detecting lysyl oxidase in vascular smooth muscle cells?

The LOX antibody has been shown to work effectively in immunoblotting applications for vascular smooth muscle cells. In a study investigating the role of survivin in regulating extracellular matrix production, the antibody was used to detect LOX expression, indicating its utility in studies related to vascular function and stiffness ().

What species can this LOX antibody be used with?

This LOX antibody is reactive with multiple species, including human, mouse, rat, bovine, and porcine. This broad reactivity makes it suitable for various experimental models across different research areas.

What applications is this LOX antibody suitable for?

The LOX antibody is suitable for several applications, including Western blotting, immunocytochemistry, immunofluorescence, and immunohistochemistry. Its versatility allows researchers to utilize it in various experimental setups to study lysyl oxidase in different contexts.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cellsAPL bioengineeringDecember 1, 2023Krajnik A, Nimmer E, Brazzo JA 3rd, Biber JC, Drewes R, Tumenbayar BI, Sullivan A, Pham K, Krug A, Heo Y, et al.fibronectin (Cat. No. F3648, Sigma-Aldrich), Cox2 (Cat. No. 66351-1-Ig, Proteintech), Lox (Cat. No. NB100-2530, Novus Biologicals), phospho-FAK (Cat. No. 3283, Cell Signaling Technology), FAK (Cat. No. ZF002, Thermo Fisher Scientific

(2) Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve diseaseBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieNovember 1, 2023Ballester-Servera C, Alonso J, Cañes L, Vázquez-Sufuentes P, Puertas-Umbert L, Fernández-Celis A, Taurón M, Rodríguez-Sinovas A, López-Andrés N, Rodríguez C, et al.

(3) Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle RegenerationDevelopmental cellMay 18, 2020Gabay Yehezkely R, Zaffryar-Eilot S, Kaganovsky A, Fainshtain Malka N, Aviram R, Livneh I, Hasson P.

(4) Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activityDevelopment (Cambridge, England)January 23, 2020Treissman J, Yuan V, Baltayeva J, Le HT, Castellana B, Robinson WP, Beristain AG.

(5) Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid CarcinomaCancersJanuary 1, 2020Minna E, Brich S, Todoerti K, Pilotti S, Collini P, Bonaldi E, Romeo P, Cecco L, Dugo M, Perrone F, et al.was assessed by using heat-induced epitope retrieval (pressure cooker) and immunostaining with anti-LOX (NB100-2530 1:400, Novus Biologicals). The assessment of α-SMA immunostaining was performed by digital quantification

(6) Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart ValvesFrontiers in cardiovascular medicineJanuary 1, 2018Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM.Novus Biologicals NB600-1531 Citrate 400 ELASTOGENESIS (Tropo)elastin Rabbit Polyclonal Abcam ab21610 Pepsin 400 Fibronectin Rabbit Polyclonal Sigma F3648 Pepsin 300 Fibrillin-1 Rabbit Polyclonal Sigma HPA017759 Pepsin 100 Fibrillin-2 Rabbit Polyclonal Sigma HPA012853 Pepsin 100 Lysil oxidase (LOX) Rabbit Polyclonal Novus Biologicals NB100-2530 Tris/EDTA 200 Fibulin-4 Rabbit Polyclonal Abonline abin1701235 Pepsin 200 Fibulin-5 Mouse 3F10A5,

(7) LOX expression in primary nasopharyngeal carcinoma: correlation with prognostic parameters and outcomeOncotargetFebruary 16, 2016Hua YJ, Wang HY, Tang LQ, Chen QY, Shao JY, Mai HQ.evaluation IHC was performed to examine LOX expression in NPC tissues using a primary LOX antibody (NB100– 2530) (1:200 dilution; Novus Biologicals, USA). The IHC results were evaluated and scored independently by

(8) Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With EndometriosisReproductive sciences (Thousand Oaks, Calif.)December 1, 2015Ruiz LA, Báez-Vega PM, Ruiz A, Peterse DP, Monteiro JB, Bracero N, Beauchamp P, Fazleabas AT, Flores I.temperature (RT) with anti-human LOX antibody (1:800 dilution, Novus Biologicals, Littleton, Colorado, cat# NB100-2530), followed by 30-minute incubation at RT with the secondary biotinylated antibody. After development

(9) Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritisProceedings of the National Academy of Sciences of the United States of AmericaJuly 28, 2015Kim JH, Lee G, Won Y, Lee M, Kwak JS, Chun CH, Chun JS.

(10) Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon CellsThe Journal of biological chemistryJune 26, 2015Herchenhan A, Uhlenbrock F, Eliasson P, Weis M, Eyre D, Kadler KE, Magnusson SP, Kjaer M.

(11) High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful WaitingPloS oneJanuary 1, 2015Nilsson M, Hägglöf C, Hammarsten P, Thysell E, Stattin P, Egevad L, Granfors T, Jernberg E, Wikstrom P, Halin Bergström S, et al.stained with primary rabbit polyclonal antibody against LOX (Novus Biologicals; Littleton CO, USA, NB100-2530, diluted 1:400). Samples were visualized using ultraView Universal DAB detection Kit (Ventana, Tuscon

(12) Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cellsExperimental eye researchAugust 1, 2013Sethi A, Wordinger RJ, Clark AF.Antibody,Ab. Dilution,Source Rabbit anti-LOX,"1:10,000",Novus Biologicals (Cat. # NB100-2530) Rabbit anti-LOXL1,1:500,Abnova (Cat. # H00004016-D01P) Mouse anti-LOXL2,1:2000,R&D Systems (Cat.

(13) A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophyMuscle & nerveJune 1, 2012Desguerre I, Arnold L, Vignaud A, Cuvellier S, Yacoub-Youssef H, Gherardi RK, Chelly J, Chretien F, Mounier R, Ferry A, et al.

(14) A peptide derived from endostatin ameliorates organ fibrosisScience translational medicineMay 30, 2012Yamaguchi Y, Takihara T, Chambers RA, Veraldi KL, Larregina AT, Feghali-Bostwick CA.

(15) Copper deficiency induced emphysema is associated with focal adhesion kinase inactivationPloS oneJanuary 1, 2012Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF.

(16) Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cellsInvestigative ophthalmology & visual scienceJuly 15, 2011Sethi A, Mao W, Wordinger RJ, Clark AF.

(17) Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidaseProceedings of the National Academy of Sciences of the United States of AmericaNovember 10, 2009Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, et al.

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