Exosome DNA purification kits allow the user to isolate of exosome-derived DNA from sources such as serum, plasma, or other bodily fluids. DNA fragments carried within exosomes or extracellular vesicles can serve as disease biomarkers, making their effective identification particularly important. These ready-to-use kits for exosome DNA extraction include specialized buffers and components designed to rapidly yield high quality material for downstream applications such as RT-PCR, and sequencing.