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Cell Biology
Biomolecules
Enzymes
Nucleases
Exonucleases
Exonucleases
Exonucleases are a broad class of enzymes that cleave off nucleotides one at a time from the 3’ or 5’ ends of DNA and RNA chains. This activity contrasts with endonucleases, which hydrolyze internal phosphodiester bonds. Biological functions of exonucleases include RNA degradation and turnover, DNA proofreading, and transcriptional regulation. In molecular biology, commercial exonucleases are available for a variety of applications:
Exonuclease I
can be used for degrading excess single-stranded primers from a mixture containing double stranded products.
Exonuclease III
can be used for unidirectional nested deletions and site-directed mutagenesis.
Lambda Exonuclease
can be used for the removal of single nucleotides from the 5’ ends in duplex DNA. Discover and compare exonucleases from different manufacturers in our
enzyme search tool
.
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Reviews
Cas9 Nuclease by IDT
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Exonuclease I
Exonuclease II
Exonuclease III
Exonuclease IV
Exonuclease V
Exonuclease VII
Lambda Exonuclease
T7 Exonuclease