The Tumor Neighborhood Watch: How Spatial Architecture and Cellular Neighborhoods Correlate to Colorectal Cancer Outcomes

Dr. Garry Nolan and his team at Stanford University collaborated with the University of Bern to conduct deep single-cell phenotyping and spatial analysis on a cohort of colorectal cancer formalin-fixed, paraffin-embedded samples using the CODEX (CO-Detection by indEXing) platform from Akoya Biosciences. As a result, the authors discovered nine distinct cellular neighborhoods, each uniquely composed of certain immune and cancer cell types. These cellular neighborhoods were found to interact with one another in a manner that correlated with disease progression and prognosis. In this webinar, Dr. Nolan will discuss the findings from the study and present an analytical framework to analyze high-dimensional imaging data that can reveal new insights into how the tumor microenvironment is organized.

Dr. Garry Nolan and his team at Stanford University collaborated with the University of Bern to conduct deep single-cell phenotyping and spatial analysis on a cohort of colorectal cancer formalin-fixed, paraffin-embedded samples using the CODEX (CO-Detection by indEXing) platform from Akoya Biosciences. As a result, the authors discovered nine distinct cellular neighborhoods, each uniquely composed of certain immune and cancer cell types. These cellular neighborhoods were found to interact with one another in a manner that correlated with disease progression and prognosis.
In this webinar, Dr. Nolan will discuss the findings from the study and present an analytical framework to analyze high-dimensional imaging data that can reveal new insights into how the tumor microenvironment is organized.

February 03, 2021

Stanford University
Department of Pathology
Dr. Garry Nolan is the Rachford and Carlota A. Harris Professor in the Department of Pathology at Stanford University.He uses multiparametric single-cell analysis to study hematopoiesis, cancer and leukemia, autoimmunity, and inflammation. His lab also develops computational approaches for network and systems immunology.Dr. Nolan received his PhD from the Department of Genetics at Stanford at the Herzenberg laboratory, and his BS in Genetics from Cornell University, and was a postdoctoral fellow in the laboratory of Dr. David Baltimore at the Massachusetts Institute of Technology and Rockefeller University. He is the author of more than 200 peer-reviewed papers and holds numerous issued patents. He was a Hume Faculty Scholar (1993–98), Trustee of the Leukemia Society of America (1995–98), Burroughs Welcome Fund New Investigator Awardee (1996–2000), HHMI Junior Faculty Scholar Awardee, Leukemia and Lymphoma Society Stohlman Scholar (2000), among others. He is the recipient of several prestigious awards and was recently honored as one of the top 25 inventors at Stanford University. He is the co-founder of 3 companies, including publicly traded RIGEL (NASDAQ:RIGL)and Nodality.