Fig 1: Angiogenesis array results. A significant increase of CCL5 expression was detected in (A) PANC-1 (P=0.0028) and (B) MIA PaCa-2 cell lines (P=0.0034) for db34a-transfected cells vs. dbSCR-transfected control cells. *P≤0.05, **P≤0.01. (C) RayBio Human Angiogenesis Array C1 map. CCL5, C-C motif chemokine ligand 5; db34a, miR-34a-3p and −5p dumbbell RNA; dbSCR, scrambled dumbbell RNA.
Fig 2: Effect of AT2R agonist C21 on the expression of angiogenic proteins in pregnant-hUAECs.The top panel presents the layout of the Human Antibody Angiogenesis Array (RayBiotech, AAH-ANG-1 and 2), including the positions of each protein. Representative images of human angiogenesis array membranes are shown in the middle panel. Normalized densitometric quantification of the arrays is shown in the bottom panel. Data were expressed as mean ± SD from three independent experiments using hUAECs from three donors. *P < 0.05 vs control.
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