Cell and gene therapies represent the next generation of human medicines, however there are several challenges to producing them, many of which are directly related to the fact that their manufacture depends on cell cultures. Cell cultures require trained laboratory technicians, are prone to contamination, and are difficult to scale up to industrial levels. This eBook provides guidance on improving the reproducibility and productivity of these cells, as well as minimizing contamination, both essential steps for manufacturing and delivering safe, effective therapies to the patients that need them the most.
Topics covered in this eBook include
- Use of luciferase reporter cancer cell lines in CAR-T development
- Generation of cell lines capable of producing high-titer viral stocks
- Utilization of quantitative mycoplasma DNA controls
- Strategies to harness biology for innovative solutions
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